Endocrine Abstracts

Pituitary hormonal status was important for the evaluation of various diseased state of hypothalamo-pituitary target organ axis as well as tumorous condition. Measurement of growth hormone (GH), adrenocorticotrophic hormone (ACTH) and cortisol during insulin-induced hypoglycaemia were commonly used to assess pituitary condition on hypoglycaemia stress. Sexual axis was evaluated with target organ hormones, i.e. estradiol or testosterone and LHRH stimulated luteinizing hormone (...

Glucagon-like peptide-1 (GLP-1) is known to stimulate insulin and somatostatin secretion in pancreatic islet cells. The exogenous somatostatin inhibits insulin secretion, but GLP-1 increases insulin secretion in spite of stimulating somatostatin secretion from δ-cell. So, we investigated whether there exists a time difference of insulin and somatostatin secretion inside the islets after GLP-1 stimulation or insulin secretion depends on secreted GLP-1 or somatostatin conce...